Calotropis gigantea stem bark extract induced apoptosis related to ROS and ATP production in colon cancer cells

• Thanwarat Winitchaikul,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medical Science, Department of Physiology, Naresuan University, Phitsanulok, Thailand

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• Suphunwadee Sawong,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medical Science, Department of Physiology, Naresuan University, Phitsanulok, Thailand

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• Damratsamon Surangkul,

  Roles Validation, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medical Science, Department of Biochemistry, Naresuan University, Phitsanulok, Thailand

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• Metawee Srikummool,

  Roles Validation, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medical Science, Department of Biochemistry, Naresuan University, Phitsanulok, Thailand

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• Julintorn Somran,

  Roles Validation, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Pathology, Naresuan University, Phitsanulok, Thailand

  https://orcid.org/0000-0001-7158-0928

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• Dumrongsak Pekthong,

  Roles Conceptualization, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Pharmaceutical Sciences, Department of Pharmacy Practice, Naresuan University, Phitsanulok, Thailand

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• Kittiya Kamonlakorn,

  Roles Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry and Pharmacognosy, Naresuan University, Phitsanulok, Thailand

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• Pranee Nangngam,

  Roles Resources, Validation, Writing – original draft

  Affiliation Faculty of Science, Department of Biology, Naresuan University, Phitsanulok, Thailand

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• Supawadee Parhira ,

  Contributed equally to this work with: Supawadee Parhira, Piyarat Srisawang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: supawadeep@nu.ac.th (SP); piyarats@nu.ac.th (PS)

  Affiliation Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Naresuan University, Phitsanulok, Thailand

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• Piyarat Srisawang

  Contributed equally to this work with: Supawadee Parhira, Piyarat Srisawang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: supawadeep@nu.ac.th (SP); piyarats@nu.ac.th (PS)

  Affiliation Faculty of Medical Science, Department of Physiology, Naresuan University, Phitsanulok, Thailand

  https://orcid.org/0000-0002-0948-8239

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