Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19

Emiko Desvaux; Antoine Hamon; Sandra Hubert; Cheïma Boudjeniba; Bastien Chassagnol; Jack Swindle; Audrey Aussy; Laurence Laigle; Jessica Laplume; Perrine Soret; Pierre Jean-François; Isabelle Dupin-Roger; Mickaël Guedj; Philippe Moingeon

doi:10.1371/journal.pone.0254374

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Open Access

Peer-reviewed

Research Article

Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19

Emiko Desvaux ,

Contributed equally to this work with: Emiko Desvaux, Antoine Hamon, Sandra Hubert, Mickaël Guedj

Roles Conceptualization, Data curation, Visualization, Writing – review & editing

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Antoine Hamon ,

Contributed equally to this work with: Emiko Desvaux, Antoine Hamon, Sandra Hubert, Mickaël Guedj

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Lincoln, Research and Development, Boulogne-Billancourt Cedex, France
⨯
Sandra Hubert ,

Contributed equally to this work with: Emiko Desvaux, Antoine Hamon, Sandra Hubert, Mickaël Guedj

Roles Conceptualization, Data curation, Visualization, Writing – review & editing

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Cheïma Boudjeniba,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Bastien Chassagnol,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Jack Swindle,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Lincoln, Research and Development, Boulogne-Billancourt Cedex, France
⨯
Audrey Aussy,

Roles Conceptualization, Formal analysis, Validation, Writing – review & editing

Affiliation Servier, Research and Development, Suresnes Cedex, France

https://orcid.org/0000-0002-3432-6223

⨯
Laurence Laigle,

Roles Conceptualization, Formal analysis, Validation, Writing – review & editing

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Jessica Laplume,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Perrine Soret,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Pierre Jean-François,

Roles Formal analysis, Investigation, Validation

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Isabelle Dupin-Roger,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Servier, Research and Development, Suresnes Cedex, France
⨯
Mickaël Guedj ,

Contributed equally to this work with: Emiko Desvaux, Antoine Hamon, Sandra Hubert, Mickaël Guedj

Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft

Affiliation Servier, Research and Development, Suresnes Cedex, France

https://orcid.org/0000-0002-9742-957X

⨯
Philippe Moingeon

Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft

* E-mail: philippe.moingeon@servier.com

Affiliation Servier, Research and Development, Suresnes Cedex, France

https://orcid.org/0000-0002-2380-9983

⨯

Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19

Emiko Desvaux,
Antoine Hamon,
Sandra Hubert,
Cheïma Boudjeniba,
Bastien Chassagnol,
Jack Swindle,
Audrey Aussy,
Laurence Laigle,
Jessica Laplume,
Perrine Soret

Published: July 22, 2021
https://doi.org/10.1371/journal.pone.0254374

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