A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox

• Ayumi Horikawa ,

  Contributed equally to this work with: Ayumi Horikawa, Keiko Mizuno

  Roles Investigation, Writing – original draft

  Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

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• Keiko Mizuno ,

  Contributed equally to this work with: Ayumi Horikawa, Keiko Mizuno

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

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• Kyoko Tsuda,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

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• Takayoshi Yamamoto,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0001-8028-6050

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• Tatsuo Michiue

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: tmichiue@bio.c.u-tokyo.ac.jp

  Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0001-9047-0513

  ⨯