Metformin intervention ameliorates AS in ApoE^-/- mice through restoring gut dysbiosis and anti-inflammation

• Ning Yan ,

  Contributed equally to this work with: Ning Yan, Lijuan Wang, Yiwei Li

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft

  Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China

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• Lijuan Wang ,

  Contributed equally to this work with: Ning Yan, Lijuan Wang, Yiwei Li

  Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Department of Cardiovascular Diseases, The Second Hospital of Yinchuan, Yinchuan, Ningxia, China

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• Yiwei Li ,

  Contributed equally to this work with: Ning Yan, Lijuan Wang, Yiwei Li

  Roles Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China

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• Ting Wang,

  Roles Data curation, Formal analysis, Software, Visualization

  Affiliation Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China

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• Libo Yang,

  Roles Conceptualization, Software

  Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China

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• Ru Yan,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China

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• Hao Wang ,

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: jsbxn@163.com (SJ); wanghaograduate@126.com (HW)

  Affiliation Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China

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• Shaobin Jia

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: jsbxn@163.com (SJ); wanghaograduate@126.com (HW)

  Affiliations Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China

  https://orcid.org/0000-0002-8545-1067

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