RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis

Ayumu Takeshita; Keiichiro Nishida; Aki Yoshida; Yoshihisa Nasu; Ryuichi Nakahara; Daisuke Kaneda; Hideki Ohashi; Toshifumi Ozaki

doi:10.1371/journal.pone.0254268

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Open Access

Peer-reviewed

Research Article

RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis

Ayumu Takeshita,

Roles Investigation, Writing – original draft

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-9699-610X

⨯
Keiichiro Nishida ,

Roles Project administration, Writing – review & editing

* E-mail: knishida@md.okayama-u.ac.jp

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Aki Yoshida,

Roles Data curation, Investigation, Methodology

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yoshihisa Nasu,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Ryuichi Nakahara,

Roles Formal analysis

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Daisuke Kaneda,

Roles Investigation

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hideki Ohashi,

Roles Investigation

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Toshifumi Ozaki

Roles Supervision

Affiliation Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis

Ayumu Takeshita,
Keiichiro Nishida,
Aki Yoshida,
Yoshihisa Nasu,
Ryuichi Nakahara,
Daisuke Kaneda,
Hideki Ohashi,
Toshifumi Ozaki

Published: July 7, 2021
https://doi.org/10.1371/journal.pone.0254268

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Chondrocytes
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Cartilage
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Articular cartilage
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Cytokines
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Synovial fluid
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Knees
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Osteoclasts
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Total knee arthroplasty
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