Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients—A mediation analysis using two observational cohorts

• Pien Swart ,

  Roles Conceptualization, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: p.swart@amsterdamumc.nl

  Affiliation Department of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-3712-7799

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• Rodrigo Octavio Deliberato,

  Roles Writing – review & editing

  Affiliations Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil, Big Data Analytics Group, Hospital Israelita Albert Einstein, São Paulo, Brazil

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• Alistair E. W. Johnson,

  Roles Conceptualization, Writing – review & editing

  Affiliation Laboratory for Computational Physiology, Institute for Medical Engineering & Science, MIT, Cambridge, MA, United States of America

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• Tom J. Pollard,

  Roles Writing – review & editing

  Affiliation Laboratory for Computational Physiology, Institute for Medical Engineering & Science, MIT, Cambridge, MA, United States of America

  https://orcid.org/0000-0002-5676-7898

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• Lucas Bulgarelli,

  Roles Writing – review & editing

  Affiliation Laboratory for Computational Physiology, Institute for Medical Engineering & Science, MIT, Cambridge, MA, United States of America

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• Paolo Pelosi,

  Roles Writing – review & editing

  Affiliations IRCCS San Martino Policlinico Hospital, Genoa, Italy, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy

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• Marcelo Gama de Abreu,

  Roles Writing – review & editing

  Affiliations Pulmonary Engineering Group, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, Outcomes Research Consortium, Cleveland, OH, United States of America

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• Marcus J. Schultz,

  Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands, Laboratory of Experimental Intensive Care and Anaesthesia (L·E·I·C·A), Amsterdam UMC, Amsterdam, The Netherlands, Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Ary Serpa Neto

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands, Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil, Pulmonary Division, Cardio–Pulmonary Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia

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