Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters

• Samit Ganguly,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Pharmacometrics, Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America

  Affiliation Cancer & Developmental Biology Track, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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• David Finkelstein,

  Roles Formal analysis

  Affiliation Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Timothy I. Shaw,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-2935-0229

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• Ryan D. Michalek,

  Roles Data curation, Resources

  Affiliation Metabolon Inc, Durham, North Carolina, United States of America

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• Kimberly M. Zorn,

  Roles Investigation

  Affiliation Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, United States of America

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• Sean Ekins,

  Roles Investigation, Resources

  Affiliation Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, United States of America

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• Kazuto Yasuda,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Yu Fukuda,

  Roles Investigation

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• John D. Schuetz,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Kamalika Mukherjee,

  Roles Visualization, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Erin G. Schuetz

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: erin.schuetz@stjude.org

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-9783-0099

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