Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program

• Chloé Sarnowski ,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  * E-mail: Chloe.Sarnowski@uth.tmc.edu

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America

  https://orcid.org/0000-0002-6090-7099

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• Han Chen,

  Roles Methodology, Software, Writing – review & editing

  Affiliations Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America, Center for Precision Health, School of Public Health and School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, United States of America

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• Mary L. Biggs,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Cardiovascular Health Unit, Department of Medicine, University of Washington, Seattle, WA, United States of America, Department of Biostatistics, University of Washington, Seattle, WA, United States of America

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• Sylvia Wassertheil-Smoller,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America

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• Jan Bressler,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America

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• Marguerite R. Irvin,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, United States of America

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• Kathleen A. Ryan,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America

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• David Karasik,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, United States of America, Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel

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• Donna K. Arnett,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation University of Kentucky, College of Public Health, Lexington, KY, United States of America

  https://orcid.org/0000-0003-2219-657X

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• L. Adrienne Cupples,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Framingham, MA, United States of America

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• David W. Fardo,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States of America

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• Stephanie M. Gogarten,

  Roles Methodology, Resources, Software, Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

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• Benjamin D. Heavner,

  Roles Methodology, Resources, Software, Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

  https://orcid.org/0000-0003-2898-9044

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• Deepti Jain,

  Roles Methodology, Resources, Software, Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

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• Hyun Min Kang,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America

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• Charles Kooperberg,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

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• Arch G. Mainous,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Health Services Research, Management and Policy, University of Florida, Gainesville, FL, United States of America

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• Braxton D. Mitchell,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America, Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, United States of America

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• Alanna C. Morrison,

  Roles Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America

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• Jeffrey R. O’Connell,

  Roles Methodology, Resources, Software, Writing – review & editing

  Affiliation Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America

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• Bruce M. Psaty,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations Cardiovascular Health Unit, Department of Medicine, University of Washington, Seattle, WA, United States of America, Departments of Epidemiology and Health Services, University of Washington, Seattle, WA, United States of America, Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States of America

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• Kenneth Rice,

  Roles Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

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• Albert V. Smith,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America

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• Ramachandran S. Vasan,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Framingham, MA, United States of America, Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America, Whitaker Cardiovascular Institute and Cardiology Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America

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• B. Gwen Windham,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation The MIND Center, University of Mississippi Medical Center, Jackson, MS, United States of America

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• Douglas P. Kiel,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, United States of America, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America, Broad Institute of Harvard & MIT, Cambridge, MA, United States of America

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• Joanne M. Murabito,

  Roles Conceptualization, Data curation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Framingham, MA, United States of America, Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America

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• Kathryn L. Lunetta,

  Roles Conceptualization, Data curation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

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• on behalf of the TOPMed Longevity and Healthy Aging Working Group ,

  ¶Membership of the TOPMed Longevity and Healthy Aging Working Group is provided in the Acknowledgments. NHLBI TOPMed Banner Authorship is provided as a S3 File.

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•  [ ... ],
• from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

  ¶Membership of the TOPMed Longevity and Healthy Aging Working Group is provided in the Acknowledgments. NHLBI TOPMed Banner Authorship is provided as a S3 File.

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