Immunoglobulin gene rearrangement in Koreans with multiple myeloma: Clonality assessment and repertoire analysis using next-generation sequencing

Miyoung Kim; Kibum Jeon; Kasey Hutt; Alyssa M. Zlotnicki; Hyo Jung Kim; Jiwon Lee; Han-Sung Kim; Hee Jung Kang; Young Kyung Lee

doi:10.1371/journal.pone.0253541

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Open Access

Peer-reviewed

Research Article

Immunoglobulin gene rearrangement in Koreans with multiple myeloma: Clonality assessment and repertoire analysis using next-generation sequencing

Miyoung Kim,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
⨯
Kibum Jeon,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Laboratory Medicine, Hangang Sacred Heart Hospital, Seoul, South Korea
⨯
Kasey Hutt,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Invivoscribe, Inc., San Diego, California, United States of America
⨯
Alyssa M. Zlotnicki,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Invivoscribe, Inc., San Diego, California, United States of America
⨯
Hyo Jung Kim,

Roles Conceptualization, Investigation, Methodology, Supervision

Affiliation Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea
⨯
Jiwon Lee,

Roles Data curation, Formal analysis, Methodology, Resources

Affiliation Department of Laboratory Medicine, Green Cross Laboratories, Yongin, South Korea
⨯
Han-Sung Kim,

Roles Methodology, Project administration, Resources

Affiliation Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea
⨯
Hee Jung Kang,

Roles Conceptualization, Investigation, Project administration, Resources

Affiliation Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea
⨯
Young Kyung Lee

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: lyoungk@hallym.or.kr

Affiliation Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea

https://orcid.org/0000-0003-0433-8028

⨯

Immunoglobulin gene rearrangement in Koreans with multiple myeloma: Clonality assessment and repertoire analysis using next-generation sequencing

Miyoung Kim,
Kibum Jeon,
Kasey Hutt,
Alyssa M. Zlotnicki,
Hyo Jung Kim,
Jiwon Lee,
Han-Sung Kim,
Hee Jung Kang,
Young Kyung Lee

Published: June 24, 2021
https://doi.org/10.1371/journal.pone.0253541

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Korean people
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Multiple myeloma
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Plasma cells
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B cells
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Bone marrow
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Next-generation sequencing
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Malignant tumors
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Neoplastic transformation
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