Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis

• Sung-Jun Park ,

  Contributed equally to this work with: Sung-Jun Park, Jay H. Chung

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: parksj2@nhlbi.nih.gov (SJP); chungj@nhlbi.nih.gov (JHC)

  Affiliation Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-6935-569X

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• Faiyaz Ahmad,

  Roles Investigation, Methodology

  Affiliation Department of Pediatric Medicine, Division of Endocrinology, Sidra Medical and Research Center, Doha, Qatar

  https://orcid.org/0000-0003-4242-2941

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• Robert J. Bahde,

  Roles Investigation, Methodology

  Current address: US Food and Drug Administration (FDA), Silver Spring, Maryland, United States of America

  Affiliation Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Andrew Philp,

  Roles Investigation, Methodology

  Affiliation Mitochondrial Metabolism and Ageing Laboratory, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Australia

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• Jeonghan Kim,

  Roles Investigation, Methodology

  Affiliation Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-1695-9630

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• Tianjiao Huang,

  Roles Investigation, Methodology

  Affiliation Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Myung K. Kim,

  Roles Conceptualization, Investigation

  Affiliation Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• William C. Trenkle,

  Roles Investigation, Methodology

  Current address: United States Department of Agriculture, Washington, D.C., United States of America

  Affiliation Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0001-7988-6921

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• Jay H. Chung

  Contributed equally to this work with: Sung-Jun Park, Jay H. Chung

  Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: parksj2@nhlbi.nih.gov (SJP); chungj@nhlbi.nih.gov (JHC)

  Affiliation Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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