SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

Christine Vazquez; Sydnie E. Swanson; Seble G. Negatu; Mark Dittmar; Jesse Miller; Holly R. Ramage; Sara Cherry; Kellie A. Jurado

doi:10.1371/journal.pone.0253089

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Peer-reviewed

Research Article

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

Christine Vazquez,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Sydnie E. Swanson,

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Seble G. Negatu,

Roles Data curation, Formal analysis

Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-6195-0312

⨯
Mark Dittmar,

Roles Investigation

Affiliation Department Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-2884-5630

⨯
Jesse Miller,

Roles Investigation

Affiliation Department Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Holly R. Ramage,

Roles Investigation

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States of America
⨯
Sara Cherry,

Roles Investigation

Affiliation Department Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Kellie A. Jurado

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft

* E-mail: kellie.jurado@pennmedicine.upenn.edu

Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-0466-2696

⨯

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

Christine Vazquez,
Sydnie E. Swanson,
Seble G. Negatu,
Mark Dittmar,
Jesse Miller,
Holly R. Ramage,
Sara Cherry,
Kellie A. Jurado

Published: June 24, 2021
https://doi.org/10.1371/journal.pone.0253089

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02 Nov 2021
14:45 GMT
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