Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy

Morven Cunningham; Marco Iafolla; Yada Kanjanapan; Orlando Cerocchi; Marcus Butler; Lillian L. Siu; Philippe L. Bedard; Kendra Ross; Bettina Hansen; Anna Spreafico; Jordan J. Feld

doi:10.1371/journal.pone.0253070

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Open Access

Peer-reviewed

Research Article

Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy

Morven Cunningham ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: morven.cunningham@uhn.ca

Affiliation Toronto Centre for Liver Disease, University Health Network, Toronto, Canada

https://orcid.org/0000-0003-2617-9523

⨯
Marco Iafolla,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Yada Kanjanapan,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Orlando Cerocchi,

Roles Formal analysis, Writing – review & editing

Affiliation Toronto Centre for Liver Disease, University Health Network, Toronto, Canada
⨯
Marcus Butler,

Roles Data curation, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Lillian L. Siu,

Roles Data curation, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Philippe L. Bedard,

Roles Data curation, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Kendra Ross,

Roles Data curation, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Bettina Hansen,

Roles Formal analysis, Writing – review & editing

Affiliation Toronto Centre for Liver Disease, University Health Network, Toronto, Canada
⨯
Anna Spreafico,

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliation Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⨯
Jordan J. Feld

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Toronto Centre for Liver Disease, University Health Network, Toronto, Canada
⨯

Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy

Morven Cunningham,
Marco Iafolla,
Yada Kanjanapan,
Orlando Cerocchi,
Marcus Butler,
Lillian L. Siu,
Philippe L. Bedard,
Kendra Ross,
Bettina Hansen,
Anna Spreafico

Published: June 11, 2021
https://doi.org/10.1371/journal.pone.0253070

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Liver
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Immunotherapy
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Cancer treatment
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