Cytoplasmic RRM1 activation as an acute response to gemcitabine treatment is involved in drug resistance of pancreatic cancer cells

• Tomotaka Kato ,

  Contributed equally to this work with: Tomotaka Kato, Hiroaki Ono

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Hiroaki Ono ,

  Contributed equally to this work with: Tomotaka Kato, Hiroaki Ono

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

  * E-mail: ono.msrg@tmd.ac.jp

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  https://orcid.org/0000-0001-9230-5714

  ⨯
• Mikiya Fujii,

  Roles Formal analysis, Investigation

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Keiichi Akahoshi,

  Roles Resources

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Toshiro Ogura,

  Roles Resources

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Kosuke Ogawa,

  Roles Resources

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Daisuke Ban,

  Roles Resources

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  https://orcid.org/0000-0003-0868-8519

  ⨯
• Atsushi Kudo,

  Roles Resources

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Shinji Tanaka,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯
• Minoru Tanabe

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

  ⨯