Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency

• Jeffrey R. Haswell ,

  Contributed equally to this work with: Jeffrey R. Haswell, Kaia Mattioli

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, United States of America

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• Kaia Mattioli ,

  Contributed equally to this work with: Jeffrey R. Haswell, Kaia Mattioli

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Chiara Gerhardinger,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Philipp G. Maass,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Genetics and Genome Biology Program, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Daniel J. Foster,

  Roles Investigation

  Affiliations Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-2466-9484

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• Paola Peinado,

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biology, University of Granada, Centre for Genomics and Oncological Research (GENYO), Granada, Spain

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• Xiaofeng Wang,

  Roles Investigation, Methodology

  Affiliation Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America

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• Pedro P. Medina,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Granada, Centre for Genomics and Oncological Research (GENYO), Granada, Spain

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• John L. Rinn,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, University of Colorado, BioFrontiers Institute, Boulder, Colorado, United States of America

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• Frank J. Slack

  Roles Conceptualization, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: fslack@bidmc.harvard.edu

  Affiliation Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-8263-0409

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