A deep transfer learning framework for the automated assessment of corneal inflammation on in vivo confocal microscopy images

Fan Xu; Yikun Qin; Wenjing He; Guangyi Huang; Jian Lv; Xinxin Xie; Chunli Diao; Fen Tang; Li Jiang; Rushi Lan; Xiaohui Cheng; Xiaolin Xiao; Siming Zeng; Qi Chen; Ling Cui; Min Li; Ningning Tang

doi:10.1371/journal.pone.0252653

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Open Access

Peer-reviewed

Research Article

A deep transfer learning framework for the automated assessment of corneal inflammation on in vivo confocal microscopy images

Fan Xu ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Yikun Qin ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Methodology, Software, Writing – original draft

Affiliation China-ASEAN Information Harbor, Nanning, Guangxi, China
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Wenjing He ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Data curation, Investigation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Guangyi Huang ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Data curation, Investigation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Jian Lv ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Data curation, Investigation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Xinxin Xie ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Investigation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Chunli Diao ,

Contributed equally to this work with: Fan Xu, Yikun Qin, Wenjing He, Guangyi Huang, Jian Lv, Xinxin Xie, Chunli Diao

Roles Investigation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Fen Tang,

Roles Validation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Li Jiang,

Roles Validation

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Rushi Lan,

Roles Methodology, Software

Affiliation Guangxi Colleges and Universities Key Laboratory of Intelligent Processing of Computer Image and Graphics, Guilin University of Electronic Technology, Guilin, Guangxi, China
⨯
Xiaohui Cheng,

Roles Software

Affiliation Guangxi Key Laboratory of Embedded Technology and Intelligent Systems, Guilin University of Technology, Guilin, Guangxi, China
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Xiaolin Xiao,

Roles Software

Affiliation School of Computer Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China
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Siming Zeng,

Roles Resources

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Qi Chen,

Roles Resources

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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Ling Cui,

Roles Resources

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
⨯
Min Li ,

Roles Funding acquisition

* E-mail: eyeminli@163.com (ML); oph_tangnn@163.com (NT)

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
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[ ... ],
Ningning Tang

Roles Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: eyeminli@163.com (ML); oph_tangnn@163.com (NT)

Affiliation Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Ophthalmology Department, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China

https://orcid.org/0000-0002-5804-0369

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A deep transfer learning framework for the automated assessment of corneal inflammation on in vivo confocal microscopy images

Fan Xu,
Yikun Qin,
Wenjing He,
Guangyi Huang,
Jian Lv,
Xinxin Xie,
Chunli Diao,
Fen Tang,
Li Jiang,
Rushi Lan

Published: June 3, 2021
https://doi.org/10.1371/journal.pone.0252653

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Inflammation
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Cornea
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Inflammatory diseases
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Dendritic cells
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Convolution
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In vivo imaging
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Fungal structure
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