Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

• Sara Elfarrash ,

  Contributed equally to this work with: Sara Elfarrash, Nanna Møller Jensen

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft

  * E-mail: saraelfarrash@mans.edu.eg (SE); phj@biomed.au.dk (PHJ)

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark, Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt, MERC–Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  https://orcid.org/0000-0002-4573-3131

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• Nanna Møller Jensen ,

  Contributed equally to this work with: Sara Elfarrash, Nanna Møller Jensen

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark

  https://orcid.org/0000-0003-1177-5197

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• Nelson Ferreira,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark

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• Sissel Ida Schmidt,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

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• Emil Gregersen,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark

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• Marie Vibeke Vestergaard,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark

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• Sadegh Nabavi,

  Roles Resources, Writing – review & editing

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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• Morten Meyer,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliations Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark, Department of Neurology, Odense University Hospital, Odense, Denmark, Department of Clinical Research, BRIDGE–Brain Research Inter-Disciplinary Guided Excellence, University of Southern Denmark, Odense, Denmark

  https://orcid.org/0000-0002-9571-1336

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• Poul Henning Jensen

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: saraelfarrash@mans.edu.eg (SE); phj@biomed.au.dk (PHJ)

  Affiliations Danish Research Institute of Translational Neuroscience–DANDRITE, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark

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