Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study

Dechao Shan; Jie Zheng; Alexander Klimowicz; Mark Panzenbeck; Zheng Liu; Di Feng

doi:10.1371/journal.pone.0252429

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Open Access

Peer-reviewed

Research Article

Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study

Dechao Shan ,

Contributed equally to this work with: Dechao Shan, Jie Zheng

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America
⨯
Jie Zheng ,

Contributed equally to this work with: Dechao Shan, Jie Zheng

Roles Data curation, Formal analysis, Project administration, Resources, Validation, Writing – review & editing

Affiliation Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America
⨯
Alexander Klimowicz ,

Roles Conceptualization, Resources, Supervision

* E-mail: alexander.klimowicz@boehringer-ingelheim.com (AK); di.feng@boehringer-ingelheim.com (DF)

Affiliation Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America
⨯
Mark Panzenbeck,

Roles Resources

Affiliation Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America
⨯
Zheng Liu,

Roles Investigation, Supervision

Affiliation Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America
⨯
Di Feng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: alexander.klimowicz@boehringer-ingelheim.com (AK); di.feng@boehringer-ingelheim.com (DF)

Affiliation Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States of America

https://orcid.org/0000-0002-0964-9995

⨯

Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study

Dechao Shan,
Jie Zheng,
Alexander Klimowicz,
Mark Panzenbeck,
Zheng Liu,
Di Feng

Published: June 14, 2021
https://doi.org/10.1371/journal.pone.0252429

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