Raman spectroscopy accurately differentiates mucosal healing from non-healing and biochemical changes following biological therapy in inflammatory bowel disease

Samuel C. L. Smith; Carl Banbury; Davide Zardo; Rosanna Cannatelli; Olga M. Nardone; Uday N. Shivaji; Subrata Ghosh; Pola Goldberg Oppenheimer; Marietta Iacucci

doi:10.1371/journal.pone.0252210

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Open Access

Peer-reviewed

Research Article

Raman spectroscopy accurately differentiates mucosal healing from non-healing and biochemical changes following biological therapy in inflammatory bowel disease

Samuel C. L. Smith,

Roles Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
⨯
Carl Banbury,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Chemical Engineering, University of Birmingham, Birmingham, United Kingdom
⨯
Davide Zardo,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
⨯
Rosanna Cannatelli,

Roles Data curation, Writing – review & editing

Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
⨯
Olga M. Nardone,

Roles Data curation, Writing – review & editing

Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

https://orcid.org/0000-0002-9554-4785

⨯
Uday N. Shivaji,

Roles Writing – review & editing

Affiliations Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom, National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

https://orcid.org/0000-0002-6800-584X

⨯
Subrata Ghosh,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
⨯
Pola Goldberg Oppenheimer,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Chemical Engineering, University of Birmingham, Birmingham, United Kingdom
⨯
Marietta Iacucci

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: m.iacucci@bham.ac.uk

Affiliations Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
⨯

Raman spectroscopy accurately differentiates mucosal healing from non-healing and biochemical changes following biological therapy in inflammatory bowel disease

Samuel C. L. Smith,
Carl Banbury,
Davide Zardo,
Rosanna Cannatelli,
Olga M. Nardone,
Uday N. Shivaji,
Subrata Ghosh,
Pola Goldberg Oppenheimer,
Marietta Iacucci

Published: June 2, 2021
https://doi.org/10.1371/journal.pone.0252210

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Inflammation
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