High-dose drug heat map analysis for drug safety and efficacy in multi-spheroid brain normal cells and GBM patient-derived cells

• Sang-Yun Lee,

  Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

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• Yvonne Teng,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Research & Development Department, AVATAMED Pte. Ltd., Singapore, Singapore

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• Miseol Son,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Research & Development Department, AVATAMED Pte. Ltd., Singapore, Singapore

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• Bosung Ku,

  Roles Methodology

  Affiliation Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

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• Ho Sang Moon,

  Roles Methodology

  Affiliation Central R & D Center, Medical & Bio Device (MBD) Co., Ltd, Suwon, Republic of Korea

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• Vinay Tergaonkar,

  Roles Writing – review & editing

  Affiliations Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore

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• Pierce Kah-Hoe Chow,

  Roles Writing – review & editing

  Affiliations Division of Surgery and Surgical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore, Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital (SGH), Singapore, Singapore, Surgery Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore, Faculty (Senior Group Leader), Genome Institute of Singapore (GIS), Singapore, Singapore, Research Director, Institute of Molecular Cell Biology (IMCB), Singapore, Singapore

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• Dong Woo Lee ,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: dw2010.lee@gmail.com (DWL); nsnam@skku.edu (DHN)

  Affiliation Department of Biomedical Engineering, Konyang University, Daejon, Korea

  https://orcid.org/0000-0003-4436-8272

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• Do-Hyun Nam

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: dw2010.lee@gmail.com (DWL); nsnam@skku.edu (DHN)

  Affiliations Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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