Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model

• Riccardo Serra ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  * E-mail: rserra@som.umaryland.edu

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-1975-393X

  ⨯
• Tianna Zhao,

  Roles Formal analysis, Investigation, Methodology, Supervision

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Sakibul Huq,

  Roles Investigation, Methodology

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Noah Leviton Gorelick,

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Joshua Casaos,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Arba Cecia,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Antonella Mangraviti,

  Roles Conceptualization, Data curation, Supervision, Writing – original draft

  Affiliation Department of Neurosurgery, School of Medicine - Catholic University of the Sacred Heart, Rome, Italy

  ⨯
• Charles Eberhart,

  Roles Data curation, Resources

  Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Renyuan Bai,

  Roles Investigation, Resources, Supervision

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Alessandro Olivi,

  Roles Conceptualization, Supervision, Writing – original draft

  Affiliation Department of Neurosurgery, School of Medicine - Catholic University of the Sacred Heart, Rome, Italy

  ⨯
• Henry Brem,

  Roles Conceptualization, Formal analysis, Resources, Supervision

  Affiliations Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Opthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Eric M. Jackson,

  Roles Conceptualization, Investigation, Resources, Supervision

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Betty Tyler

  Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Supervision, Writing – original draft

  Affiliation Department of Neurosurgery, Hunterian Neurosurgical Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯