Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice

Alexandre Boyer; Xiangfan Zhang; Adrien Levasseur; Nour Abou Nader; Guillaume St-Jean; Makoto C. Nagano; Derek Boerboom

doi:10.1371/journal.pone.0251911

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Open Access

Peer-reviewed

Research Article

Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice

Alexandre Boyer ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliation Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada

https://orcid.org/0000-0001-7539-0056

⨯
Xiangfan Zhang ,

Roles Formal analysis, Investigation

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Obstetrics and Gynecology, Division of Reproductive Biology, Faculty of Medicine, McGill University, Montréal, Québec, Canada
⨯
Adrien Levasseur,

Roles Investigation

Current address: Génétique Reproduction & Développement, CNRS UMR 6293, Inserm U1103, Université Clermont Auvergne, Clermont-Ferrand, France

Affiliation Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada

https://orcid.org/0000-0001-9933-3478

⨯
Nour Abou Nader,

Roles Investigation

Affiliation Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada
⨯
Guillaume St-Jean,

Roles Formal analysis

Affiliation Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada
⨯
Makoto C. Nagano,

Roles Formal analysis, Funding acquisition

Affiliation Department of Obstetrics and Gynecology, Division of Reproductive Biology, Faculty of Medicine, McGill University, Montréal, Québec, Canada
⨯
Derek Boerboom

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: derek.boerboom@umontreal.ca

Affiliation Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada
⨯

Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice

Alexandre Boyer,
Xiangfan Zhang,
Adrien Levasseur,
Nour Abou Nader,
Guillaume St-Jean,
Makoto C. Nagano,
Derek Boerboom

Published: May 20, 2021
https://doi.org/10.1371/journal.pone.0251911

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Spermatogonia
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Germ cells
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Spermatogenesis
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Testes
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Cell differentiation
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Gene expression
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Gene regulation
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