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Open Access
Peer-reviewed
Research Article
A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
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Jitendra S. Kanshana,
Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Polly E. Mattila,
Roles Investigation, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Michael C. Ewing,
Roles Investigation, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Ashlee N. Wood,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Gabriele Schoiswohl,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Pharmacology and Toxicology, University of Graz, Graz, Austria
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Anna C. Meyer,
Roles Investigation, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Aneta Kowalski,
Roles Investigation, Writing – review & editing
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Samantha L. Rosenthal,
Roles Investigation, Writing – review & editing
Affiliation Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA, United States of America
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Sebastien Gingras,
Roles Methodology, Resources, Writing – review & editing
Affiliation Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States of America
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Brett A. Kaufman,
Roles Methodology, Resources, Writing – review & editing
Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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Ray Lu,
Roles Methodology, Resources, Writing – review & editing
Affiliation Department of Molecular and Cellular Biology, College of Biological Science, University of Guelph, Guelph, ON, Canada
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Daniel E. Weeks,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Stephen T. McGarvey,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations International Health Institute, Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, United States of America, Department of Anthropology, Brown University, Providence, Rhode Island, United States of America
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Ryan L. Minster,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Nicola L. Hawley,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America
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Erin E. Kershaw
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: kershawe@pitt.edu
Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America
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A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
- Jitendra S. Kanshana,
- Polly E. Mattila,
- Michael C. Ewing,
- Ashlee N. Wood,
- Gabriele Schoiswohl,
- Anna C. Meyer,
- Aneta Kowalski,
- Samantha L. Rosenthal,
- Sebastien Gingras,
- Brett A. Kaufman
- Published: September 14, 2021
- https://doi.org/10.1371/journal.pone.0251895