Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

• Janna Krueger ,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Division of Immuno-Oncology, Research Center Maisonneuve-Rosemont Hospital (CR-HMR) Montreal, Quebec, Canada, Department of Microbiology, Infection and Immunology, Universite de Montreal, Montreal, Quebec, Canada

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• Francois Santinon ,

  Roles Investigation, Methodology

  ¶‡ These authors share first authorship on this work.

  Affiliations Division of Immuno-Oncology, Research Center Maisonneuve-Rosemont Hospital (CR-HMR) Montreal, Quebec, Canada, Department of Microbiology, Infection and Immunology, Universite de Montreal, Montreal, Quebec, Canada

  ⨯
• Alexandra Kazanova ,

  Roles Conceptualization, Data curation, Validation

  ¶‡ These authors share first authorship on this work.

  Affiliations Division of Immuno-Oncology, Research Center Maisonneuve-Rosemont Hospital (CR-HMR) Montreal, Quebec, Canada, Department of Microbiology, Infection and Immunology, Universite de Montreal, Montreal, Quebec, Canada

  ⨯
• Mark E. Issa,

  Roles Investigation, Methodology

  Affiliations Division of Immuno-Oncology, Research Center Maisonneuve-Rosemont Hospital (CR-HMR) Montreal, Quebec, Canada, Department of Microbiology, Infection and Immunology, Universite de Montreal, Montreal, Quebec, Canada

  https://orcid.org/0000-0002-0854-4147

  ⨯
• Bruno Larrivee,

  Roles Conceptualization, Investigation, Writing – original draft

  Affiliation Department of Ophthalmology, Universite de Montreal, Montreal, Quebec, Canada

  ⨯
• Richard Kremer,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Division of Experimental Medicine, Department of Medicine, McGill University Health Center, Montreal, Canada

  ⨯
• Catalin Milhalcioiu,

  Roles Conceptualization, Writing – review & editing

  Affiliation Division of Medical Oncology, Department of Medicine, McGill University Health Center, Montreal, Canada

  ⨯
• Christopher E. Rudd

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: christopher.e.rudd@umontreal.ca

  ¶‡ These authors share first authorship on this work.

  Affiliations Division of Immuno-Oncology, Research Center Maisonneuve-Rosemont Hospital (CR-HMR) Montreal, Quebec, Canada, Department of Microbiology, Infection and Immunology, Universite de Montreal, Montreal, Quebec, Canada, Division of Experimental Medicine, Department of Medicine, McGill University Health Center, Montreal, Canada

  https://orcid.org/0000-0001-5295-9019

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