Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program

Rebecca J. Song; Yuk-Lam Ho; Petra Schubert; Yojin Park; Daniel Posner; Emily M. Lord; Lauren Costa; Hanna Gerlovin; Katherine E. Kurgansky; Tori Anglin-Foote; Scott DuVall; Jennifer E. Huffman; Saiju Pyarajan; Jean C. Beckham; Kyong-Mi Chang; Katherine P. Liao; Luc Djousse; David R. Gagnon; Stacey B. Whitbourne; Rachel Ramoni; Sumitra Muralidhar; Philip S. Tsao; Christopher J. O’Donnell; John Michael Gaziano; Juan P. Casas; Kelly Cho; on behalf of the VA Million Veteran Program COVID-19 Science Initiative

doi:10.1371/journal.pone.0251651

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Open Access

Peer-reviewed

Research Article

Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program

Rebecca J. Song ,

Contributed equally to this work with: Rebecca J. Song, Yuk-Lam Ho

Roles Conceptualization, Data curation, Methodology, Writing – original draft

* E-mail: Rebecca.Song@va.gov

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-8431-1698

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Yuk-Lam Ho ,

Contributed equally to this work with: Rebecca J. Song, Yuk-Lam Ho

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Petra Schubert,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Yojin Park,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-6849-3556

⨯
Daniel Posner,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
⨯
Emily M. Lord,

Roles Project administration

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
⨯
Lauren Costa,

Roles Project administration

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Hanna Gerlovin,

Roles Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-6700-2129

⨯
Katherine E. Kurgansky,

Roles Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Tori Anglin-Foote,

Roles Data curation

Affiliation VA Salt Lake City Health Care System, Salt Lake City, Utah, United States of America

https://orcid.org/0000-0002-9084-7111

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Scott DuVall,

Roles Data curation

Affiliations VA Salt Lake City Health Care System, Salt Lake City, Utah, United States of America, Office of Research and Development, Veterans Health Administration, Washington, DC, United States of America, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Jennifer E. Huffman,

Roles Writing – review & editing

Affiliation Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Saiju Pyarajan,

Roles Data curation

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Division of Aging, Brigham & Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Jean C. Beckham,

Roles Writing – review & editing

Affiliations Durham VA Medical Center, Durham, North Carolina, United States of America, Department of Psychiatry and Behavioral Sciences, University Medical Center, Durham, North Carolina, United States of America, VA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham, North Carolina, United States of America
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Kyong-Mi Chang,

Roles Writing – review & editing

Affiliations Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Katherine P. Liao,

Roles Writing – review & editing

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Luc Djousse,

Roles Writing – review & editing

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Division of Aging, Brigham & Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David R. Gagnon,

Roles Writing – review & editing

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
⨯
Stacey B. Whitbourne,

Roles Writing – review & editing

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Rachel Ramoni,

Roles Funding acquisition, Resources

Affiliation Office of Research and Development, Veterans Health Administration, Washington, DC, United States of America
⨯
Sumitra Muralidhar,

Roles Funding acquisition, Resources

Affiliation Office of Research and Development, Veterans Health Administration, Washington, DC, United States of America
⨯
Philip S. Tsao,

Roles Funding acquisition, Resources

Affiliations Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America, VA Palo Alto Health Care System, Palo Alto, California, United States of America
⨯
Christopher J. O’Donnell,

Roles Funding acquisition, Resources

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
John Michael Gaziano,

Roles Funding acquisition, Resources, Supervision

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Division of Aging, Brigham & Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Juan P. Casas,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Division of Aging, Brigham & Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kelly Cho,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft

Affiliations Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Medicine, Division of Aging, Brigham & Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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[ ... ],
on behalf of the VA Million Veteran Program COVID-19 Science Initiative

¶Membership of the VA Million Veteran Program COVID-19 Science Initiative is provided in S1 File.
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Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program

Rebecca J. Song,
Yuk-Lam Ho,
Petra Schubert,
Yojin Park,
Daniel Posner,
Emily M. Lord,
Lauren Costa,
Hanna Gerlovin,
Katherine E. Kurgansky,
Tori Anglin-Foote

Published: May 13, 2021
https://doi.org/10.1371/journal.pone.0251651

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