Mapping Rora expression in resting and activated CD4+ T cells

Liora Haim-Vilmovsky; Johan Henriksson; Jennifer A. Walker; Zhichao Miao; Eviatar Natan; Gozde Kar; Simon Clare; Jillian L. Barlow; Evelina Charidemou; Lira Mamanova; Xi Chen; Valentina Proserpio; Jhuma Pramanik; Steven Woodhouse; Anna V. Protasio; Mirjana Efremova; Julian L. Griffin; Matt Berriman; Gordon Dougan; Jasmin Fisher; John C. Marioni; Andrew N. J. McKenzie; Sarah A. Teichmann

doi:10.1371/journal.pone.0251233

Loading metrics

Open Access

Peer-reviewed

Research Article

Mapping Rora expression in resting and activated CD4+ T cells

Liora Haim-Vilmovsky ,

Contributed equally to this work with: Liora Haim-Vilmovsky, Johan Henriksson

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Johan Henriksson ,

Contributed equally to this work with: Liora Haim-Vilmovsky, Johan Henriksson

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden; Department of Molecular Biology, Umeå University, Umeå, Sweden

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

https://orcid.org/0000-0002-7745-2844

⨯
Jennifer A. Walker,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft

Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
⨯
Zhichao Miao,

Roles Formal analysis

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

https://orcid.org/0000-0002-5777-9815

⨯
Eviatar Natan,

Roles Data curation, Investigation, Validation

Current address: The Aleph Lab, Oxford, United Kingdom

Affiliation EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Gozde Kar,

Roles Formal analysis

Current address: Translational Medicine, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Simon Clare,

Roles Investigation

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Jillian L. Barlow,

Roles Investigation, Validation

Current address: Department of Biology, University of York, Wentworth Way, York, United Kingdom

Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
⨯
Evelina Charidemou,

Roles Investigation

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Lira Mamanova,

Roles Investigation

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Xi Chen,

Roles Investigation

Current address: Department of Biology, South University of Science and Technology of China, Shenzhen, China

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Valentina Proserpio,

Roles Investigation, Writing – review & editing

Current address: IIGM Foundation–Italian Institute for Genomic Medicine, Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

https://orcid.org/0000-0003-2071-4206

⨯
Jhuma Pramanik,

Roles Investigation

Current address: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Steven Woodhouse,

Roles Formal analysis

Current address: Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Affiliations Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Anna V. Protasio,

Roles Investigation

Current address: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Mirjana Efremova,

Roles Formal analysis

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Julian L. Griffin,

Roles Resources

Affiliations Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, Department of Metabolism, Digestion and Reproduction, Biomolecular Medicine, Imperial College London, London, United Kingdom
⨯
Matt Berriman,

Roles Resources

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

https://orcid.org/0000-0002-9581-0377

⨯
Gordon Dougan,

Roles Resources

Affiliation Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Jasmin Fisher,

Roles Resources, Supervision

Current address: UCL Cancer Institute, University College London, London, United Kingdom

Affiliation Microsoft Research, Cambridge, United Kingdom
⨯
John C. Marioni,

Roles Conceptualization, Resources, Supervision, Writing – original draft

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Andrew N. J. McKenzie,

Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
⨯
[ ... ],
Sarah A. Teichmann

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

* E-mail: st9@sanger.ac.uk

Affiliations EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, Theory of Condensed Matter, Cavendish Laboratory, Cambridge, United Kingdom

https://orcid.org/0000-0002-6294-6366

⨯
[ view all ]
[ view less ]

Mapping Rora expression in resting and activated CD4+ T cells

Liora Haim-Vilmovsky,
Johan Henriksson,
Jennifer A. Walker,
Zhichao Miao,
Eviatar Natan,
Gozde Kar,
Simon Clare,
Jillian L. Barlow,
Evelina Charidemou,
Lira Mamanova

Published: May 18, 2021
https://doi.org/10.1371/journal.pone.0251233

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T helper cells
Is the Subject Area "T helper cells" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Lymph nodes
Is the Subject Area "Lymph nodes" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.