GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration

Chloe Delepine; Vincent A. Pham; Hayley W. S. Tsang; Mriganka Sur

doi:10.1371/journal.pone.0251173

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Peer-reviewed

Research Article

GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration

Chloe Delepine,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0002-1856-9583

⨯
Vincent A. Pham,

Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliations Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0001-7083-9360

⨯
Hayley W. S. Tsang,

Roles Data curation, Formal analysis

Affiliations Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Mriganka Sur

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: msur@mit.edu

Affiliations Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Simons Center for the Social Brain, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration

Chloe Delepine,
Vincent A. Pham,
Hayley W. S. Tsang,
Mriganka Sur

Published: May 5, 2021
https://doi.org/10.1371/journal.pone.0251173

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Neuronal differentiation
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