CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

Yoshiko Oyama; Shogo Shigeta; Hideki Tokunaga; Keita Tsuji; Masumi Ishibashi; Yusuke Shibuya; Muneaki Shimada; Jun Yasuda; Nobuo Yaegashi

doi:10.1371/journal.pone.0251079

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Open Access

Peer-reviewed

Research Article

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

Yoshiko Oyama,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Shogo Shigeta,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Hideki Tokunaga ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: hideki.tokunaga.a1@tohoku.ac.jp

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Keita Tsuji,

Roles Conceptualization, Funding acquisition, Resources

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Masumi Ishibashi,

Roles Conceptualization, Methodology, Resources, Validation

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yusuke Shibuya,

Roles Conceptualization, Methodology, Supervision

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Muneaki Shimada,

Roles Conceptualization, Resources, Supervision

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Jun Yasuda,

Roles Conceptualization, Supervision

Affiliation Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Miyagi, Japan
⨯
Nobuo Yaegashi

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

Yoshiko Oyama,
Shogo Shigeta,
Hideki Tokunaga,
Keita Tsuji,
Masumi Ishibashi,
Yusuke Shibuya,
Muneaki Shimada,
Jun Yasuda,
Nobuo Yaegashi

Published: June 23, 2021
https://doi.org/10.1371/journal.pone.0251079

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Ovarian cancer
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Platinum
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Small interfering RNA
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Transfection
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Apoptosis
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DNA damage
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Polymerase chain reaction
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