Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

• Debra Van Egeren ,

  Contributed equally to this work with: Debra Van Egeren, Alexander Novokhodko, Madison Stoddard

  Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Systems Biology, Harvard Medical School, Boston, MA, United States of America, Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States of America, Stem Cell Program, Boston Children’s Hospital, Boston, MA, United States of America

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• Alexander Novokhodko ,

  Contributed equally to this work with: Debra Van Egeren, Alexander Novokhodko, Madison Stoddard

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Mechanical Engineering, University of Washington, Seattle, WA, United States of America

  https://orcid.org/0000-0002-8975-6730

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• Madison Stoddard ,

  Contributed equally to this work with: Debra Van Egeren, Alexander Novokhodko, Madison Stoddard

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Fractal Therapeutics, Cambridge, MA, United States of America

  https://orcid.org/0000-0001-9853-8500

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• Uyen Tran,

  Roles Data curation, Investigation, Visualization, Writing – review & editing

  Affiliation Fractal Therapeutics, Cambridge, MA, United States of America

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• Bruce Zetter,

  Roles Supervision, Writing – review & editing

  Affiliation Vascular Biology Program, Boston Children’s Hospital, Boston, MA, United States of America

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• Michael Rogers,

  Roles Supervision, Writing – review & editing

  Affiliation Vascular Biology Program, Boston Children’s Hospital, Boston, MA, United States of America

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• Bradley L. Pentelute,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States of America

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• Jonathan M. Carlson,

  Roles Supervision, Writing – review & editing

  Affiliation Microsoft Research, Redmond, WA, United States of America

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• Mark Hixon,

  Roles Supervision, Writing – review & editing

  Affiliation Mark S. Hixon Consulting, LLC, San Diego, CA, United States of America

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• Diane Joseph-McCarthy,

  Roles Supervision, Writing – review & editing

  Affiliation Boston University, Boston, MA, United States of America

  https://orcid.org/0000-0001-9685-6177

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• Arijit Chakravarty

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: arijit@fractal.tx

  Affiliation Fractal Therapeutics, Cambridge, MA, United States of America

  https://orcid.org/0000-0003-1338-5432

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