Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave

Nicola Sweeney; Blair Merrick; Rui Pedro Galão; Suzanne Pickering; Alina Botgros; Harry D. Wilson; Adrian W. Signell; Gilberto Betancor; Mark Kia Ik Tan; John Ramble; Neophytos Kouphou; Sam Acors; Carl Graham; Jeffrey Seow; Eithne MacMahon; Stuart J. D. Neil; Michael H. Malim; Katie Doores; Sam Douthwaite; Rahul Batra; Gaia Nebbia; Jonathan D. Edgeworth

doi:10.1371/journal.pone.0249791

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Open Access

Peer-reviewed

Research Article

Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave

Nicola Sweeney,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Blair Merrick ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: blair.merrick@nhs.net

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0002-6061-6064

⨯
Rui Pedro Galão,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0003-3368-5053

⨯
Suzanne Pickering,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Alina Botgros,

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Harry D. Wilson,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Adrian W. Signell,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Gilberto Betancor,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Mark Kia Ik Tan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Affiliation Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0002-7774-3836

⨯
John Ramble,

Roles Conceptualization, Investigation, Methodology, Resources, Validation

Affiliation Infection Sciences, Viapath LLP, St Thomas’ Hospital, London, United Kingdom
⨯
Neophytos Kouphou,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0002-4945-8640

⨯
Sam Acors,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0001-6428-7707

⨯
Carl Graham,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Jeffrey Seow,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Eithne MacMahon,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
⨯
Stuart J. D. Neil,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Michael H. Malim,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Katie Doores,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0002-5507-1725

⨯
Sam Douthwaite,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
⨯
Rahul Batra,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
⨯
Gaia Nebbia,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
⨯
[ ... ],
Jonathan D. Edgeworth

Roles Conceptualization, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
⨯
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Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave

Nicola Sweeney,
Blair Merrick,
Rui Pedro Galão,
Suzanne Pickering,
Alina Botgros,
Harry D. Wilson,
Adrian W. Signell,
Gilberto Betancor,
Mark Kia Ik Tan,
John Ramble

Published: April 7, 2021
https://doi.org/10.1371/journal.pone.0249791

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