Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

• Darta Maija Zake,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia

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• Janis Kurlovics,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland

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• Linda Zaharenko,

  Roles Conceptualization, Data curation, Methodology, Resources, Writing – review & editing

  Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

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• Vitalijs Komasilovs,

  Roles Project administration, Software, Supervision, Writing – review & editing

  Affiliation Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia

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• Janis Klovins,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

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• Egils Stalidzans

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: egils.stalidzans@gmail.com

  Affiliations Latvian Biomedical Research and Study Centre, Riga, Latvia, Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia

  https://orcid.org/0000-0001-6063-0184

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