Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

George Z. Wei; Sujata Saraswat Ohri; Nicolas K. Khattar; Adam W. Listerman; Catherine H. Doyle; Kariena R. Andres; Saravanan S. Karuppagounder; Rajiv R. Ratan; Scott R. Whittemore; Michal Hetman

doi:10.1371/journal.pone.0249591

Loading metrics

Open Access

Peer-reviewed

Research Article

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

George Z. Wei,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliations University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States of America, Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Sujata Saraswat Ohri,

Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

Affiliations Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Nicolas K. Khattar,

Roles Investigation

Affiliations Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States of America, Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Adam W. Listerman,

Roles Investigation

Affiliation Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Catherine H. Doyle,

Roles Investigation

Affiliations Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Kariena R. Andres,

Roles Investigation

Affiliation Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America
⨯
Saravanan S. Karuppagounder,

Roles Formal analysis, Investigation, Resources, Writing – review & editing

Affiliations Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute, White Plains, NY, United States of America, Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY, United States of America
⨯
Rajiv R. Ratan,

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliations Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute, White Plains, NY, United States of America, Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY, United States of America
⨯
Scott R. Whittemore ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: swhittemore@louisville.edu (SRW); michal.hetman@louisville.edu (MH)

Affiliations Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States of America, Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, United States of America

https://orcid.org/0000-0001-6437-7200

⨯
Michal Hetman

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

* E-mail: swhittemore@louisville.edu (SRW); michal.hetman@louisville.edu (MH)

Affiliations University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY, United States of America, Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States of America, Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, United States of America

https://orcid.org/0000-0002-4305-8478

⨯

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

George Z. Wei,
Sujata Saraswat Ohri,
Nicolas K. Khattar,
Adam W. Listerman,
Catherine H. Doyle,
Kariena R. Andres,
Saravanan S. Karuppagounder,
Rajiv R. Ratan,
Scott R. Whittemore,
Michal Hetman

Published: April 5, 2021
https://doi.org/10.1371/journal.pone.0249591

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Biological locomotion
Is the Subject Area "Biological locomotion" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Spinal cord injury
Is the Subject Area "Spinal cord injury" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Neuronal death
Is the Subject Area "Neuronal death" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.