Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies

• Daniel P. Wickland,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America, National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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• Yingxue Ren,

  Roles Data curation, Investigation

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America

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• Jason P. Sinnwell,

  Roles Data curation, Methodology

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, United States of America

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• Joseph S. Reddy,

  Roles Data curation

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America

  https://orcid.org/0000-0002-1783-4453

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• Cyril Pottier,

  Roles Data curation

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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• Vivekananda Sarangi,

  Roles Formal analysis

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, United States of America

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• Minerva M. Carrasquillo,

  Roles Investigation

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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• Owen A. Ross,

  Roles Investigation

  Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Department of Clinical Genomics, Mayo Clinic, Jacksonville, Florida, United States of America

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• Steven G. Younkin,

  Roles Investigation

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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• Nilüfer Ertekin-Taner,

  Roles Investigation

  Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

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• Rosa Rademakers,

  Roles Investigation

  Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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• Matthew E. Hudson,

  Roles Funding acquisition, Methodology, Resources, Supervision

  Affiliations National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Carl R. Woese Institute for Genomic Biology, Carver Biotechnology Center and Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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• Liudmila Sergeevna Mainzer,

  Roles Conceptualization, Methodology, Resources, Supervision

  Affiliations National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Carl R. Woese Institute for Genomic Biology, Carver Biotechnology Center and Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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• Joanna M. Biernacka,

  Roles Methodology, Supervision

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, United States of America

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• Yan W. Asmann

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: Asmann.Yan@mayo.edu

  Affiliation Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America

  https://orcid.org/0000-0002-8896-2647

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