Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

Jason A. West; Anastasia Tsakmaki; Soumitra S. Ghosh; David G. Parkes; Rikke V. Grønlund; Philip J. Pedersen; David Maggs; Harith Rajagopalan; Gavin A. Bewick

doi:10.1371/journal.pone.0249239

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Open Access

Peer-reviewed

Research Article

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

Jason A. West,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Fractyl Laboratories Inc, Lexington, MA, United States of America

https://orcid.org/0000-0002-7252-8651

⨯
Anastasia Tsakmaki,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, England, United Kingdom
⨯
Soumitra S. Ghosh,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Doon Associates LLC, San Diego, CA, United States of America

https://orcid.org/0000-0002-7405-0436

⨯
David G. Parkes,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation DGP Scientific Inc, San Diego, CA, United States of America
⨯
Rikke V. Grønlund,

Roles Investigation

Affiliation Gubra ApS, Hørsholm, Denmark
⨯
Philip J. Pedersen,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Gubra ApS, Hørsholm, Denmark
⨯
David Maggs,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Current address: Becton Dickinson Technologies & Innovation, Raleigh-Durham, NC, United States of America

Affiliation Fractyl Laboratories Inc, Lexington, MA, United States of America
⨯
Harith Rajagopalan,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Fractyl Laboratories Inc, Lexington, MA, United States of America
⨯
Gavin A. Bewick

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

* E-mail: gavin.bewick@kcl.ac.uk

Affiliation Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, England, United Kingdom
⨯

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

Jason A. West,
Anastasia Tsakmaki,
Soumitra S. Ghosh,
David G. Parkes,
Rikke V. Grønlund,
Philip J. Pedersen,
David Maggs,
Harith Rajagopalan,
Gavin A. Bewick

Published: March 31, 2021
https://doi.org/10.1371/journal.pone.0249239

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