Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

Diane Heiser; Joëlle Rubert; Adeline Unterreiner; Claudine Maurer; Marion Kamke; Ursula Bodendorf; Christopher J. Farady; Ben Roediger; Frédéric Bornancin

doi:10.1371/journal.pone.0248668

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Open Access

Peer-reviewed

Research Article

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

Diane Heiser ,

Contributed equally to this work with: Diane Heiser, Joëlle Rubert, Adeline Unterreiner

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Joëlle Rubert ,

Contributed equally to this work with: Diane Heiser, Joëlle Rubert, Adeline Unterreiner

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Adeline Unterreiner ,

Contributed equally to this work with: Diane Heiser, Joëlle Rubert, Adeline Unterreiner

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Claudine Maurer,

Roles Methodology

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Marion Kamke,

Roles Methodology

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Ursula Bodendorf,

Roles Visualization

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Christopher J. Farady,

Roles Visualization

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Ben Roediger,

Roles Visualization, Writing – review & editing

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland
⨯
Frédéric Bornancin

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: frederic.bornancin@novartis.com

Affiliation Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland

https://orcid.org/0000-0002-0152-6720

⨯

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

Diane Heiser,
Joëlle Rubert,
Adeline Unterreiner,
Claudine Maurer,
Marion Kamke,
Ursula Bodendorf,
Christopher J. Farady,
Ben Roediger,
Frédéric Bornancin

Published: November 12, 2021
https://doi.org/10.1371/journal.pone.0248668

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Inflammasomes
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Immunoblot analysis
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Phosphorylation
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Secretion
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Biomarkers
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Immunoblotting
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Protease inhibitor therapy
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