Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

Lesley-Ann Giddings; George T. Lountos; Kang Woo Kim; Matthew Brockley; Danielle Needle; Scott Cherry; Joseph E. Tropea; David S. Waugh

doi:10.1371/journal.pone.0248385

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Open Access

Peer-reviewed

Research Article

Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

Lesley-Ann Giddings ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: lgiddings@smith.edu

Affiliations Department of Chemistry, Smith College, Northampton, MA, United States of America, Department of Chemistry & Biochemistry, Middlebury College, Middlebury, VT, United States of America

https://orcid.org/0000-0003-1089-1276

⨯
George T. Lountos,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America

https://orcid.org/0000-0003-3463-8881

⨯
Kang Woo Kim,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Chemistry & Biochemistry, Middlebury College, Middlebury, VT, United States of America
⨯
Matthew Brockley,

Roles Formal analysis, Investigation

Affiliation Department of Chemistry & Biochemistry, Middlebury College, Middlebury, VT, United States of America
⨯
Danielle Needle,

Roles Investigation

Affiliation Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America
⨯
Scott Cherry,

Roles Investigation

Affiliation Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America
⨯
Joseph E. Tropea,

Roles Investigation

Affiliation Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America
⨯
David S. Waugh

Roles Supervision

Affiliation Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America
⨯

Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

Lesley-Ann Giddings,
George T. Lountos,
Kang Woo Kim,
Matthew Brockley,
Danielle Needle,
Scott Cherry,
Joseph E. Tropea,
David S. Waugh

Published: March 30, 2021
https://doi.org/10.1371/journal.pone.0248385

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