Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Evelyn M. Mrozek; Vineeta Bajaj; Yanan Guo; Izabela A. Malinowska; Jianming Zhang; David J. Kwiatkowski

doi:10.1371/journal.pone.0248380

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Open Access

Peer-reviewed

Research Article

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Evelyn M. Mrozek ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: dk@rics.bwh.harvard.edu (DJK); evelyn.mrozek@gmail.com (EMM)

Affiliation Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Vineeta Bajaj,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yanan Guo,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Izabela A. Malinowska,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jianming Zhang,

Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David J. Kwiatkowski

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: dk@rics.bwh.harvard.edu (DJK); evelyn.mrozek@gmail.com (EMM)

Affiliation Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-5668-5219

⨯

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Evelyn M. Mrozek,
Vineeta Bajaj,
Yanan Guo,
Izabela A. Malinowska,
Jianming Zhang,
David J. Kwiatkowski

Published: April 23, 2021
https://doi.org/10.1371/journal.pone.0248380

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