Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity

Hongwei Shao; Mecker Moller; Long Cai; Rochelle Prokupets; Cuixia Yang; Connor Costa; Kerstin Yu; Nga Le; Zhao-Jun Liu

doi:10.1371/journal.pone.0248260

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Open Access

Peer-reviewed

Research Article

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity

Hongwei Shao,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Mecker Moller,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Long Cai,

Roles Data curation, Formal analysis, Investigation, Methodology

Current address: Hangzhou Red-Cross Hospital, Hangzhou, Zhejiang Province, China

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Rochelle Prokupets,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Cuixia Yang,

Roles Formal analysis, Investigation, Methodology

Current address: Department of Molecular Biology Laboratory, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Connor Costa,

Roles Writing – review & editing

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Kerstin Yu,

Roles Formal analysis, Investigation

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Nga Le,

Roles Visualization, Writing – review & editing

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America
⨯
Zhao-Jun Liu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: zliu@med.miami.edu

Affiliation Department of Surgery, University of Miami School of Medicine, Miami, Florida, United States of America

https://orcid.org/0000-0002-2301-0768

⨯

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity

Hongwei Shao,
Mecker Moller,
Long Cai,
Rochelle Prokupets,
Cuixia Yang,
Connor Costa,
Kerstin Yu,
Nga Le,
Zhao-Jun Liu

Published: March 11, 2021
https://doi.org/10.1371/journal.pone.0248260

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Notch signaling
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Melanoma cells
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Cancers and neoplasms
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Melanoma
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Fibroblasts
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Malignant tumors
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Metastasis
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Microarrays
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