Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133+ cells

Swojani Shrestha; Sandeep Singhal; Donald A. Sens; Seema Somji; Bethany A. Davis; Rachel Guyer; Spencer Breen; Matthew Kalonick; Scott H. Garrett

doi:10.1371/journal.pone.0248241

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Open Access

Peer-reviewed

Research Article

Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133⁺ cells

Swojani Shrestha,

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Sandeep Singhal,

Roles Formal analysis

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Donald A. Sens,

Roles Conceptualization, Funding acquisition, Writing – original draft

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Seema Somji,

Roles Data curation, Investigation

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Bethany A. Davis,

Roles Data curation

Affiliation Translational Genomics Research Institute, Phoenix, Arizona, United States of America

https://orcid.org/0000-0001-9477-0847

⨯
Rachel Guyer,

Roles Data curation

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Spencer Breen,

Roles Conceptualization

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Matthew Kalonick,

Roles Data curation

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Scott H. Garrett

Roles Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: scott.garrett@und.edu

Affiliation Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America

https://orcid.org/0000-0002-4398-9213

⨯

Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133⁺ cells

Swojani Shrestha,
Sandeep Singhal,
Donald A. Sens,
Seema Somji,
Bethany A. Davis,
Rachel Guyer,
Spencer Breen,
Matthew Kalonick,
Scott H. Garrett

Published: March 25, 2021
https://doi.org/10.1371/journal.pone.0248241

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Glucose
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Lysosomes
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Gene expression
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Cell staining
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Kidneys
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Immunofluorescence staining
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DAPI staining
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Stem cells
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