Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells

Hong Cao; Li Qiang; Jing Chen; Katherine M. Johnson; Mark A. McNiven; Gina L. Razidlo

doi:10.1371/journal.pone.0248111

Loading metrics

Open Access

Peer-reviewed

Research Article

Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells

Hong Cao ,

Contributed equally to this work with: Hong Cao, Li Qiang

Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

Affiliation Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Li Qiang ,

Contributed equally to this work with: Hong Cao, Li Qiang

Roles Formal analysis, Investigation, Writing – original draft

Affiliations Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Jing Chen,

Roles Formal analysis, Investigation

Affiliation Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Katherine M. Johnson,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Mark A. McNiven ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: razidlo.gina@mayo.edu (GLR); mcniven.mark@mayo.edu (MAM)

Affiliations Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America

https://orcid.org/0000-0002-9830-1885

⨯
Gina L. Razidlo

Roles Funding acquisition, Writing – review & editing

* E-mail: razidlo.gina@mayo.edu (GLR); mcniven.mark@mayo.edu (MAM)

Affiliations Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells

Hong Cao,
Li Qiang,
Jing Chen,
Katherine M. Johnson,
Mark A. McNiven,
Gina L. Razidlo

Published: March 19, 2021
https://doi.org/10.1371/journal.pone.0248111

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Extracellular matrix
Is the Subject Area "Extracellular matrix" applicable to this article?

Thanks for your feedback.
Stromal cells
Is the Subject Area "Stromal cells" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Pancreatic cancer
Is the Subject Area "Pancreatic cancer" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.
Gelatin
Is the Subject Area "Gelatin" applicable to this article?

Thanks for your feedback.
Proteases
Is the Subject Area "Proteases" applicable to this article?

Thanks for your feedback.