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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
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Steven A. Saenz ,
Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing
* E-mail: steven.saenz@bms.com (SAS); michael.ellis@bms.com (JME)
Affiliation Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America
⨯ - Andrea Local,
- Tiffany Carr,
- Arvind Shakya,
- Shivsmriti Koul,
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Haiqing Hu,
Roles Data curation, Formal analysis
Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America
⨯ - Lisa Chourb,
- Justin Stedman,
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Jenna Malley,
Roles Formal analysis
Current address: Takeda Pharmaceuticals, Cambridge, Massachusetts, United States of America
Affiliation Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America
⨯ - Laura Akullian D’Agostino,
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Veerabahu Shanmugasundaram,
Roles Visualization
Affiliation Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America
⨯ - John Malona,
- C. Eric Schwartz,
- Lisa Beebe,
- Meghan Clements,
- Ganesh Rajaraman,
- John Cho,
- Lan Jiang,
- Alex Dubrovskiy,
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Matt Kreilein,
Roles Formal analysis, Supervision
Affiliation Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America
⨯ -
Roman Shimanovich,
Roles Formal analysis, Supervision
Affiliation Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America
⨯ - Lawrence G. Hamann,
- Laure Escoubet,
- [ ... ],
- J. Michael Ellis
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https://orcid.org/0000-0003-3537-7580
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
- Steven A. Saenz,
- Andrea Local,
- Tiffany Carr,
- Arvind Shakya,
- Shivsmriti Koul,
- Haiqing Hu,
- Lisa Chourb,
- Justin Stedman,
- Jenna Malley,
- Laura Akullian D’Agostino
- Published: November 9, 2021
- https://doi.org/10.1371/journal.pone.0248034