Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3

Katelyn J. McCann; Manoj Yadav; Mohammadali E. Alishahedani; Alexandra F. Freeman; Ian A. Myles

doi:10.1371/journal.pone.0248011

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Peer-reviewed

Research Article

Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3

Katelyn J. McCann,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Manoj Yadav,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliations Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America, Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Mohammadali E. Alishahedani,

Roles Investigation, Writing – review & editing

Affiliations Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America, Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Alexandra F. Freeman,

Roles Conceptualization, Investigation, Supervision, Validation

Affiliation Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America
⨯
Ian A. Myles

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mylesi@niaid.nih.gov

Affiliations Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America, Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

https://orcid.org/0000-0001-9316-3703

⨯

Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3

Katelyn J. McCann,
Manoj Yadav,
Mohammadali E. Alishahedani,
Alexandra F. Freeman,
Ian A. Myles

Published: March 4, 2021
https://doi.org/10.1371/journal.pone.0248011

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Keloids
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Fibroblasts
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Folic acid
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Mitochondria
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Cultured fibroblasts
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Glycolysis
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Scars
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Cell metabolism
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