Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

Jingjing He; Desheng Kong; Zhifen Yang; Ruiyun Guo; Asiamah Ernest Amponsah; Baofeng Feng; Xiaolin Zhang; Wei Zhang; Aijing Liu; Jun Ma; Timothy O’Brien; Huixian Cui

doi:10.1371/journal.pone.0247662

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Open Access

Peer-reviewed

Research Article

Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

Jingjing He,

Roles Writing – original draft

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Desheng Kong,

Roles Data curation

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Zhifen Yang,

Roles Formal analysis

Affiliation The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Ruiyun Guo,

Roles Writing – original draft

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Asiamah Ernest Amponsah,

Roles Writing – original draft, Writing – review & editing

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Baofeng Feng,

Roles Writing – review & editing

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Xiaolin Zhang,

Roles Writing – original draft

Affiliation Department of Epidemiology and Health Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Wei Zhang,

Roles Writing – review & editing

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China
⨯
Aijing Liu,

Roles Formal analysis

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China, Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Jun Ma ,

Roles Conceptualization, Supervision, Validation, Writing – review & editing

* E-mail: junmahmu@163.com (JM); timothy.obrien@nuigalway.ie (TO); huixiancuihmu@163.com (HC)

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China, Human Anatomy Department, Hebei Medical University, Shijiazhuang, Hebei Province, China

https://orcid.org/0000-0003-2843-0769

⨯
Timothy O’Brien ,

Roles Conceptualization

* E-mail: junmahmu@163.com (JM); timothy.obrien@nuigalway.ie (TO); huixiancuihmu@163.com (HC)

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China, Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, Galway, Ireland

https://orcid.org/0000-0001-9028-5481

⨯
Huixian Cui

Roles Conceptualization

* E-mail: junmahmu@163.com (JM); timothy.obrien@nuigalway.ie (TO); huixiancuihmu@163.com (HC)

Affiliations Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei Province, China, Hebei Research Center for Stem Cell Medical Translational Engineering, Shijiazhuang, Hebei Province, China, Human Anatomy Department, Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯

Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

Jingjing He,
Desheng Kong,
Zhifen Yang,
Ruiyun Guo,
Asiamah Ernest Amponsah,
Baofeng Feng,
Xiaolin Zhang,
Wei Zhang,
Aijing Liu,
Jun Ma

Published: March 11, 2021
https://doi.org/10.1371/journal.pone.0247662

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Mesenchymal stem cells
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Diabetes mellitus
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Stem cell therapy
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Insulin
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Randomized controlled trials
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