Berberine ameliorates vascular dysfunction by a global modulation of lncRNA and mRNA expression profiles in hypertensive mouse aortae

Na Tan; Yi Zhang; Yan Zhang; Li Li; Yi Zong; Wenwen Han; Limei Liu

doi:10.1371/journal.pone.0247621

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Open Access

Peer-reviewed

Research Article

Berberine ameliorates vascular dysfunction by a global modulation of lncRNA and mRNA expression profiles in hypertensive mouse aortae

Na Tan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Yi Zhang,

Roles Data curation, Resources, Validation

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Yan Zhang,

Roles Visualization

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
⨯
Li Li,

Roles Visualization

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
⨯
Yi Zong,

Roles Investigation

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Wenwen Han,

Roles Investigation

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
⨯
Limei Liu

Roles Conceptualization, Funding acquisition, Validation, Visualization, Writing – review & editing

* E-mail: liu_limei@126.com

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

https://orcid.org/0000-0002-8518-6822

⨯

Berberine ameliorates vascular dysfunction by a global modulation of lncRNA and mRNA expression profiles in hypertensive mouse aortae

Na Tan,
Yi Zhang,
Yan Zhang,
Li Li,
Yi Zong,
Wenwen Han,
Limei Liu

Published: February 23, 2021
https://doi.org/10.1371/journal.pone.0247621

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Long non-coding RNA
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Hypertension
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Microarrays
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Gene expression
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Calcium signaling
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Endothelial cells
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Blood pressure
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Gene ontologies
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