Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells

• Yen-Huang Cheng ,

  Roles Conceptualization, Funding acquisition, Investigation

  ¶‡ These authors jointly supervise this work and own equal contribution to this research.

  Affiliation Department of Emergency Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan

  ⨯
• En-Pei Isabel Chiang ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation

  ¶‡ These authors jointly supervise this work and own equal contribution to this research.

  Affiliations Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, Innovation and Development Center of Sustainable Agriculture (IDCSA), National Chung Hsing University, Taichung, Taiwan

  ⨯
• Jia-Ning Syu ,

  Roles Data curation, Investigation

  ¶‡ These authors jointly supervise this work and own equal contribution to this research.

  Affiliation Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan

  ⨯
• Che-Yi Chao,

  Roles Formal analysis, Resources

  Affiliations Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

  ⨯
• Hung-Yu Lin,

  Roles Formal analysis

  Affiliation Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan

  ⨯
• Cheng-Chieh Lin,

  Roles Resources

  Affiliations School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan, Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan

  ⨯
• Mei-Due Yang,

  Roles Resources

  Affiliation Department of Surgery, China Medical University Hospital, Taichung, Taiwan

  ⨯
• Shu-Yao Tsai,

  Roles Resources

  Affiliation Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan

  ⨯
• Feng-Yao Tang

  Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: vincenttang@mail.cmu.edu.tw

  Current address: Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan

  Affiliation Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan

  https://orcid.org/0000-0002-7861-2643

  ⨯