Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver

• Roxana Khatib Shahidi,

  Roles Formal analysis, Writing – original draft

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Jenny M. Hoffmann,

  Roles Formal analysis, Writing – original draft

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Shahram Hedjazifar,

  Roles Formal analysis, Writing – original draft

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Laurianne Bonnet,

  Roles Formal analysis, Writing – original draft

  Affiliations The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden

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• Ritesh K. Baboota,

  Roles Formal analysis, Writing – original draft

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Stephanie Heasman,

  Roles Formal analysis, Writing – original draft

  Affiliation Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

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• Christopher Church,

  Roles Formal analysis, Writing – original draft

  Affiliation Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

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• Ivet Elias,

  Roles Methodology

  Affiliation Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)

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• Fatima Bosch,

  Roles Methodology

  Affiliation Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)

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• Jeremie Boucher,

  Roles Supervision, Writing – original draft

  Affiliations The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden, Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Ann Hammarstedt,

  Roles Formal analysis, Writing – original draft

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Ulf Smith

  Roles Conceptualization, Validation, Writing – original draft, Writing – review & editing

  * E-mail: ulf.smith@medic.gu.se

  Affiliation The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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