Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection

• Cristina Mussini ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cristina.mussini@unimore.it

  ¶‡ These authors share first authorship to this work.

  Affiliations Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy

  https://orcid.org/0000-0002-6615-4198

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• Alessandro Cozzi-Lepri ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship to this work.

  Affiliation Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, UCL Population Health Sciences, University College London, London, United Kingdom

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• Marianna Menozzi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

  ⨯
• Marianna Meschiari,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

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• Erica Franceschini,

  Roles Conceptualization, Data curation, Investigation

  Affiliation Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

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• Jovana Milic,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy

  ⨯
• Lucio Brugioni,

  Roles Investigation, Supervision

  Affiliation Internal Medicine Department, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

  ⨯
• Antonello Pietrangelo,

  Roles Data curation, Investigation

  Affiliation Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

  https://orcid.org/0000-0002-7411-935X

  ⨯
• Massimo Girardis,

  Roles Data curation, Investigation

  Affiliations Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy, Department of Anaesthesia and Intensive Care Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

  ⨯
• Andrea Cossarizza,

  Roles Data curation, Investigation, Supervision

  Affiliation Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

  ⨯
• Roberto Tonelli,

  Roles Data curation, Investigation

  Affiliation Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

  ⨯
• Enrico Clini,

  Roles Data curation, Investigation, Supervision

  Affiliations Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy, Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy

  ⨯
• Marco Massari,

  Roles Data curation, Methodology, Supervision

  Affiliation Infectious Disease Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

  ⨯
• Michele Bartoletti,

  Roles Data curation, Investigation

  Affiliation Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

  ⨯
• Anna Ferrari,

  Roles Data curation, Investigation

  Affiliation Infectious Disease Unit, Azienda Ospedale, University of Padua, Padua, Italy

  ⨯
• Anna Maria Cattelan,

  Roles Data curation, Investigation, Supervision, Writing – review & editing

  Affiliation Infectious Disease Unit, Azienda Ospedale, University of Padua, Padua, Italy

  ⨯
• Paola Zuccalà,

  Roles Data curation, Methodology

  Affiliation Department of Public Health and Infectious Disease, Sapienza University of Rome, Polo Pontino, Italy

  ⨯
• Miriam Lichtner,

  Roles Data curation, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Public Health and Infectious Disease, Sapienza University of Rome, Polo Pontino, Italy

  ⨯
• Roberto Rossotti,

  Roles Data curation, Investigation, Supervision

  Affiliation Niguarda Hospital Milan, Milano, Italy

  https://orcid.org/0000-0003-4965-8789

  ⨯
• Enrico Girardi,

  Roles Data curation, Investigation, Supervision

  Affiliation National Institute for Infectious Diseases L. Spallanzani (INMI), Rome, Italy

  ⨯
• Emanuele Nicastri,

  Roles Data curation, Investigation, Supervision

  Affiliation National Institute for Infectious Diseases L. Spallanzani (INMI), Rome, Italy

  ⨯
• Massimo Puoti,

  Roles Data curation, Investigation, Supervision

  Affiliations National Institute for Infectious Diseases L. Spallanzani (INMI), Rome, Italy, School of Medicine, Università degli studi di Milano Bicocca, Milano, Italy

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• Andrea Antinori,

  Roles Data curation, Investigation, Supervision

  Affiliation National Institute for Infectious Diseases L. Spallanzani (INMI), Rome, Italy

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• Pierluigi Viale,

  Roles Data curation, Investigation, Supervision

  Affiliation Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

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•  [ ... ],
• Giovanni Guaraldi

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy

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