Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

• Randall C. Mazzarino,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

  Affiliations Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, United States of America, Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, United States of America, Department of Biological Sciences, University of Denver, Denver, Colorado, United States of America, Molecular and Cellular Biophysics Program, University of Denver, Denver, Colorado, United States of America

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• Veronika Baresova,

  Roles Resources

  Affiliation Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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• Marie Zikánová,

  Roles Resources

  Affiliation Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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• Nathan Duval,

  Roles Investigation, Methodology

  Affiliations Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, United States of America, Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, United States of America, Department of Biological Sciences, University of Denver, Denver, Colorado, United States of America

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• Terry G. Wilkinson II,

  Roles Investigation

  Affiliations Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, United States of America, Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, United States of America

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• David Patterson,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, United States of America, Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, United States of America, Department of Biological Sciences, University of Denver, Denver, Colorado, United States of America

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• Guido N. Vacano

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: guido.vacano@du.edu

  Affiliations Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, United States of America, Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, United States of America

  https://orcid.org/0000-0001-5979-9310

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