Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy

• Akihiro Shitara ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: shitaraa@med.akita-u.ac.jp

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

  https://orcid.org/0000-0003-0293-9372

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• Kazumasa Takahashi,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Mayumi Goto,

  Roles Investigation, Resources, Validation, Visualization

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Harunori Takahashi,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Takuya Iwasawa,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Yohei Onodera,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Kenichi Makino,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Hiroshi Miura,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Hiromitsu Shirasawa,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Wataru Sato,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Yukiyo Kumazawa,

  Roles Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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• Yukihiro Terada

  Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine Hondo, Akita, Japan

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