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Open Access
Peer-reviewed
Research Article
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease
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Tanu Rana,
Roles Investigation, Methodology, Validation
Affiliation Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America
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Olga Y. Korolkova,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America
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Girish Rachakonda,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Department of Microbiology and Immunology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America
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Amanda D. Williams,
Roles Data curation, Writing – review & editing
Affiliation Department of Biology, Lipscomb University, Nashville, Tennessee, United States of America
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Alexander T. Hawkins,
Roles Conceptualization, Writing – review & editing
Affiliation Division of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Samuel D. James,
Roles Conceptualization, Investigation
Affiliations Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America, Department of Pathology, Microbiology, and Immunology, Tennessee Valley Health Systems VA Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Amos M. Sakwe,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Graduate Studies and Research, Nashville, Tennessee, United States of America
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Nian Hui,
Roles Formal analysis, Software
Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Li Wang,
Roles Formal analysis, Software
Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Chang Yu,
Roles Data curation, Investigation, Methodology, Software
Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Jeffrey S. Goodwin,
Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing
Affiliation Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America
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Michael G. Izban,
Roles Formal analysis, Validation, Writing – review & editing
Affiliation Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Regina S. Offodile,
Roles Writing – review & editing
Affiliation Department of Professional and Medical Education, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Mary K. Washington,
Roles Conceptualization, Investigation
Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Billy R. Ballard,
Roles Conceptualization
Affiliation Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Duane T. Smoot,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Medicine, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Xuan-Zheng Shi,
Roles Conceptualization, Investigation
Affiliation Department of Medicine, University of Texas Medical Branch (UTMB) in Galveston, Galveston, Texas, United States of America
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Digna S. Forbes,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Anil Shanker,
Roles Conceptualization, Data curation, Investigation, Writing – review & editing
Affiliation Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America
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Amosy E. M’Koma
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: amkoma@mmc.edu, amosy.e.mkoma@vumc.org
Affiliations Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, Tennessee, United States of America, Division of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, Tennessee, United States of America
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Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease
- Tanu Rana,
- Olga Y. Korolkova,
- Girish Rachakonda,
- Amanda D. Williams,
- Alexander T. Hawkins,
- Samuel D. James,
- Amos M. Sakwe,
- Nian Hui,
- Li Wang,
- Chang Yu
- Published: March 9, 2021
- https://doi.org/10.1371/journal.pone.0246393