A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy

Joel Crespo; Yi Ting Koh; Ningjie Hu; Paul A. Moore; Ezio Bonvini; Andrew L. Glasebrook; Andrea P. Martin; Robert J. Benschop

doi:10.1371/journal.pone.0245917

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Open Access

Peer-reviewed

Research Article

A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy

Joel Crespo,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America

https://orcid.org/0000-0002-4776-7909

⨯
Yi Ting Koh,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America
⨯
Ningjie Hu,

Roles Formal analysis, Writing – review & editing

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America
⨯
Paul A. Moore,

Roles Project administration, Writing – review & editing

Affiliation MacroGenics, Rockville, MD, United States of America
⨯
Ezio Bonvini,

Roles Investigation, Methodology, Writing – review & editing

Affiliation MacroGenics, Rockville, MD, United States of America
⨯
Andrew L. Glasebrook,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America
⨯
Andrea P. Martin ,

Contributed equally to this work with: Andrea P. Martin, Robert J. Benschop

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Current address: Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, United States of America

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America
⨯
Robert J. Benschop

Contributed equally to this work with: Andrea P. Martin, Robert J. Benschop

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: benschop_robert@lilly.com

Affiliation Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States of America
⨯

A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy

Joel Crespo,
Yi Ting Koh,
Ningjie Hu,
Paul A. Moore,
Ezio Bonvini,
Andrew L. Glasebrook,
Andrea P. Martin,
Robert J. Benschop

Published: February 17, 2021
https://doi.org/10.1371/journal.pone.0245917

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